I know it's not the caliber you're interested in, but the 327Federal Magnum has merit if you reload for it. Ballistics are interesting - it has at least as much boom as the very best 9mm+P+ loads.
http://www.gunblast.com/Ruger-327s.htm
Ruger just started shipping a special edition Single Six in 327 with a seven-shot cylinder!
http://www.ruger.com/products/newModelSingleSixDE/models.html
That might just be exactly what you're looking for - the Single Six is the Ruger "small frame" and this is by far the most potent chambering the Single Six has ever seen (and it's a "seven" not a six).
I would really, really like one of those guns myself.
http://www.gunblast.com/Ruger-327s.htm
Ruger just started shipping a special edition Single Six in 327 with a seven-shot cylinder!
http://www.ruger.com/products/newModelSingleSixDE/models.html
That might just be exactly what you're looking for - the Single Six is the Ruger "small frame" and this is by far the most potent chambering the Single Six has ever seen (and it's a "seven" not a six).
I would really, really like one of those guns myself.