I began my career in personal security during the aftermath of Hurricane Andrew in '92.
That was a mess. Looters were everywhere in Homestead and a bunch of people were killed afterward during the looting and tent city antics.
I'd already lived through Hurricane Hugo as a senior in High School in 89, so when Andrew hit I kinda knew what to expect.
Natural disaster stuff is really sticky, and if I had a family, I'd put them all on Dual purpose motorcycles, give them handguns with three magazines and send them out of the perimeter with water (camelbacks) and fuel. The Kawasaki KLR 650 gets about 50mpg and holds 6.1 gallons of fuel.
If I had to stay in the middle of it all, (which I wouldn't want to despite my awesome vinyl record collection I'd want to save.) I'd probably rely on the two weeks or so of canned food I keep all the time. When I say canned, I mean pickles, tomatoes, venison, squash, etc, in addition to canned soup and stuff. And, I have a water purifier in my ruck, so I'd be okay filtering water for up to 250 gallons. I also have a camp stove and 6 bottles of fuel at all times.
But weapons? Well, the shotgun is my first choice. Rem. 870 with xtended mag. Can't beat a scattergun for visual appeal. After all, looters are just looking for an easy mark. In addition to buckshot, birdshot, and rocksalt, I'd want (but don't have) flechette rounds just in case some wise guy in a tac vest tried to test my skills. But, of course, I have a bow for that...
Other than the scattergun, the .45 cal single action and a .357 sp101. Scattergun has a tac-sling and a bandolier to go with it. SP101 has speedloaders and would be a cinch for my S/O to use.
I'd toss my Ruger P345 to any would be assailants so I'd feel better about swapping lead with them.
I'd only trust that PILE with my life if someone was pointing it at me.