I think the Glock 20 is the most versatile semiautomatic hand gun. Without any need of gunsmithing, only the ability to handload, the 10mm can be used to plink with light loads, defend hearth and home with premium loads and hunt with hot loads to light loads. (Depending upon what is being hunted.)
With a simple barrel swap, and maybe a different recoil spring, you can shoot .357 SIG to 9X25 Dillon.
With a simple barrel swap, and maybe a different recoil spring, you can shoot .357 SIG to 9X25 Dillon.