I think the highlights have been hit, but the number one reason (I think) 45 Colt is still around is because it, along with 44-40, were the first two calibers to be indisputable man stoppers.
Looking back from 1873 there are a bunch of pistols and calibers to choose from, but if you were serious about open carry SD on either side of the law that year, it came down to one of those two. Since then we got .45ACP, and the velocity wars.
I think the 45LC/410 revolvers have helped increase interest in 45 Colt lately.
I think the popularity of CAS shooting has helped the popularity of 45 Colt lately.
As a reloader, I too find 45 Colt to be an extremely versatile cartridge to reload.
For SD I find the 3.75" Ruger New Vaquero with birdhead grip (see post #6 above- the pretty black one at the top of the picture) to conceal very easily; even with surfer shorts and a baggy Tshirt, ass/u/ming high quality belt. It is a terrific belly gun, and quite the little fire breather rated to 20k psi with a handful of 270SAA bullets fronting any of dozens of powders.
I secretly want a 2" version of same just likethe gentleman from Tennsee.
For the Lower 48 I would be comfortable hunting any game anywhere with a tier II 45Colt psitol as a sidearm. 20k psi - like the New Vaquero, most of the SW model 25s and similar - pushing 270 to 300gr bullets- and with an appropriate rifle as primary arm - I would (and will) be comfortable in remote Rocky Mtn grizzly country, FL swamp gator country, LA bayou gator country, CO mountain lions, in the Lower 48 you bring it and I'll bring a 45 Colt loaded to 20k psi.
For Alaska, yeah, I gt a Redhawk. 32k psi load limit (commonly referred to as tier III in reloading circles) , bullet weights up to 340-360grs, yeah, for big coastal salmon fed bear, I'll take the Rdhawk. For the Alaskan interior, (between the Alaska and Brooks mountain ranges) I am comfortablewith 20k psi.
Plus, loaded up wth Holy Black, I get the same grin I get rubbing to gold coins together thinking of Julius Ceasar.