My powder of choice has always been W748 for .223 in my Ruger #1 heavy varmit. To be honest, I probably only tried 3 or 4 powders (4198, 4895, 3031) before settling on W748. That was 30 years ago. With .75MOA groups, I just quit, figuring the rifle was better than me and trying for anything better was just wasting barrel.
With only a couple pounds of W748 on hand (and locally unavailable) and 1100 .223 brass to load, it was recommended on this forum that I try BLC-2. Taking that advice and with an 8 lb keg of BLC2 in hand, I've loaded some mid range charge rounds to test in my AR. They cycle and fire fine, just haven't had a chance to check for accuracy at the range yet. These are really just range rounds, so I'm not looking for ultimate accuracy with my AR. I'm not planning to work up a load for max accuracy with the BLC2 at this point. I'll try them in my #1 at some point, but with quite a bit of carefully crafted ammo for the #1, It would only be an interesting experiment.