Whether I use QuiclLOAD or data from Hodgdon's published measurements, going from 48.5 grains of IMR 4064 to 49.5 grains (a 1.0-grain span or ±0.5 grains), I get a 46 fps velocity difference. With the 150-grain Hornady FMJ, at 200 yards the total drop difference is 0.3 inches. So, by itself, that isn't enough to matter. What will matter is whether your barrel times change the angle of departure enough to see the difference at 200. The odds are good they won't be. However, if you shoot a ladder to see that you are in the middle of a deadspot in muzzle rise or fall with your center load value, that is what will offer the most immunity to charge error at that range. It won't be that 46 fps number unless your SD is zero. It will be more like the 46 fps addition plus your highest extreme spread number at 49.5 grains verses not having the added 46 fps and the lowest extreme spread number. If you suppose that takes you across about 100 fps of velocity range, you have more like a 0.8" drop difference. Still pretty hard to see with a service rifle target.