A potential solution can be found in the Taurus line of handguns. Looking at their compact, concealed carry, mid and full size lines, you will find that their guns are left handed, i.e. both safety and slide release are on the left side. I did a cursory search, you'll need to see which are poly/steel.
I purchased the G2 last year (9mm) and have begun to train with it. This is a compact poly/steel handgun and will be my carry once my CCW arrives. Also, this is a "hammer-less" weapon. At first I thought I had made a mistake after ordering it. I had been working with hammer based hand guns up until my point of purchase (Canik Stingray and CZ 75 P01), didn't even think to consider it. When I took the gun to the range and began to work with it I realized I had made the right choice, for carry at least. The large frame Taurus' do have hammers. Truthfully, I don't understand why a hammer-based gun is so important? Does it really matter how a gun is cocked, that you can or can't control the hammer? Either way, your end goal is to cleanly release the safety and defend yourself if necessary.
Good luck with your search.