Most reliable, durable...
I guess I'd say a double action revolver from Ruger, Smith and Wesson, or Colt. Probably in that order because of the price. All three IMhO are quality firearms.
A Glock 10 mm is sure an interesting idea - a powerful caliber in a reliable gun that is easy to use. As you know, once the Glock is loaded it is just point and shoot - no safety, no need to cock it.
HOWEVER - what happens when it misfires -especially in a high-stress self-defense situation?
Double action revolver you just pull the trigger again. (And you were going to pull the trigger again anyway, weren't you?)
Semi-auto you must do some form of the tap-rack-bang dance to get it into action again.
If you practice a lot the misfire drill can become second nature to you but there is no denying it is just way more fool proof to point the DA revolver and pull the trigger again.
P.S. 10mm ammo may be a little hard to find and a little pricey too. The .38 special, .357 magnum, .44 magnum and .45 Colt can be found in a lot more stores.