Assuming we are talking handguns, and speaking theoretically, I'd probably go with my S&W M&P45c.
The shorter grip is slightly easier to conceal than the grip on the full-size. The compact will accept the full-size magazines, so I can carry 8+1 with a flush-fitting magazine on strong-side, and carry 10rd spares in the mag holder weak-side. (For that matter, I have some 14rd mags, but those are more for the vault in my truck; kind of awkward for carry on the body.)
My M&Ps feed anything I've tried. No stoppages with either one to date. And while I have not yet started reloading, there is an abundance of data for loading .45acp, and people I know who do reload say it's a very forgiving round for a new reloader.
With the large backstrap equipped, the M&P is a perfect fit for my hand, and points ridiculously well. (I have long hands; most people I know use the medium grip.)
The M&P is highly modular, so for those who want the ability to install (or remove) a thumb safety, or magazine disconnect safety, it's a good choice. I like mine without either the thumb or mag safeties, so that's how they are configured.
I like that it's made in America, too, by an American company with a fantastic reputation for both quality control and customer service.
While the .45acp would not be my first choice for defense from 4-legged critters, there are loads that would make it at least a not-too-inadequate choice. Frankly, I am normally not concerned with boar and bear; in my neck of the woods, I suppose mountain lions are a remote possibility, but a .45 will work just fine on those (assuming one sees the kitty in time). My main concern is with 2-legged critters, and the .45acp has a pretty good track record with those.
It's also not a terribly expensive gun to replace, should it get damaged, etc. Even with the additions I've made (Apex kits, Heinie Straight-8 sights), the pistol would cost less to replace than would most SIGs.
There is good aftermarket support for the gun, too. Holsters and sights are plentiful.
Luckily for me, I don't have to limit myself to just one.