Handgun: Unique = target velocities up to pretty stout hunting rounds. Also a great rifle cast bullet powder, and of course shotgun...20, 16, & 12...there are loads for it. Win 231 might work nearly as well as Unique, tho you wouldn't be able to get as high velocity with it...but it meters a hellofa lot better than old "Flaming Dirt"!
Rifle: Unique, again, for light gallery loads up to deer killers with cast bullets, and 4895 or 4064 for all the rest. You can't get top velocities with either, but for hunting and targets out to 300 +, they'll do and with fine accuracy as well.
Shotgun: Unique again, tho there may be better choices for the three gages mentioned nowadays. I haven't loaded for shotgun in 20 years...about the time when lead shot prices went through the roof for the first time.
So what's that come to: Unique, 4895 and Unique or some more current shotgun powder.
YMMv Rod