I know this thread has all but expired, but I was poking around here and wanted to add my two cents. Besides, with the fall not too far off, many of us will be working on our handloads for the hunt(s), so maybe a revival isn't a bad thing.
By no means is this meant to stir the pot, but last year I took a 200lb Blacktail with regular old 150gr Rem. CoreLokt (the $13/box walmart variety), out of a Savage 30/06 @ 20yds. Now, perhaps the close range was a factor, but the animal took one step (he was in a light trot) and dropped. As for the bullet, it pretty much snapped one rib and ruptured the heart, breaking into two chunks, penatrating about halfway through the chest. However, there was no exit wound.