I shot a nice buck about 7 years ago with a Ruger M-77 in 30-06. The ammo I was using was a 220 Gr. Winchester Silvertip. Upon impact, behind the front left shoulder, he jumped up and kicked his hind legs and thought he was going to face plant right there. Instead, he took off and took me and my dad on a 5 hour trek.
We never did find that deer, even when we enlisted the help of some of my cousins to track it. In talking with some other hunters, they said that the 220gr. just punched a hole in him and that a lighter bullet would have closed the deal. That's possible, but I'm fairly certain that he died considering the blood trail he left. That box of 220s is still in my ammo box, half-full and I'm hesitant to use them again.