I've owned 10 S&W revolvers over the years and while I don't keep an exact round count, a few of them easily have thousands of rounds through them since I've owned them (most were bought used). Of those revolvers, I've only had two which had problems beyond what I'd consider normal maintenance/wear and tear that I could address myself (tightening ejector rods, installing endshake bearings, etc.).
The first was my 629-6 which broke a firing pin while shooting Hornady factory 300 gr XTP ammo. To be fair, however, the ammo in question seemed as though it was probably running on the upper end of pressure, if not overpressure, as the primers were noticeably flattened and the cases extracted a little sticky, so I don't know if that may have contributed to the problem. S&W fixed the problem without hesitation under warranty and I had my gun back in about two weeks. I've never had a moment's trouble with the revolver since and that's been over six years ago with many, many rounds in between.
The other was my Model 28-2 which broke it's trigger stud while I was installing a new rebound slide spring. To be fair, I bought this revolver used (and it was well-used at that) and I don't know how many times it may have been disassembled before or if it had been disassembled and reassembled correctly. I did have to pay to have this one fixed as it predated the lifetime warranty and I was not the original owner. While it was back at Springfield, I also had it reblued, retimed, and the barrel-cylinder gap reset (this revolver has sentimental value to me, so resale value or how much I have in it aren't really a concern). It took a few months, but what I got back was even better than I expected: the reblue job was gorgeous (I had them stay with the original satin blue) and the action is timed like a Swiss watch and locks up like a bank vault.
The other S&W revolvers I own or have owned include Models 10, 13, 22, 27, 36, 57, 66, and 442 and they've all been flawless save for the occasional case of shooter error or maintenance.