It's reasonable to assume that, as with rifle cartridges, there are differences in the inherent accuracy of different handgun cartridges. However, while that is academically interesting, very few shooters can shoot up to the potential of their guns, and still fewer guns can shoot up to the potential of their cartridges. In a typical handgun, excluding the various stockless rifles like the XP-100s and so forth, there are far too many moving parts for real accuracy. But for the things we use handguns to do, it doesn't matter much. You don't need a half MOA pistol to shoot a squirrel or a robber at 10 yards. On the day that I can hold a 1.5" group at 25 yards from standing, I'll worry about it.