I have a bunch of calibers and have killed big game with everything from a .22 up to a .375. After 40 years of this hunting stuff I think the following is true. Big bullets, (if your body can handle them), are superior to little bullets. Big and fast usually beats small and fast. Big bullets leave big holes and makes game tracking easier because there is usually more blood trail. That doesn't mean I don't think smaller cartridges won't get the job done. Often they do wonderful. I don't wish to hurt anyones feelings by insulting their favorite deer-wacker. However, if I have so much invested in a trip that to muff it by shooting a marginal gun during a critical moment would cause great emotional pain, I go with the largest gun I can comfortably shoot. As I get older recoil does bother me a little more but I tend to still shoot hotter cartridges. Let me ask the question a different way. Do you think the deer, the Kudu or a large bear knows what they have been shot with? Of course not. However, if the shock of terminal velocity is not great enough, you may have a problem.