I've did it for years (CZ 75B, Glock 22, Ruger GP100 4", 1911, XD 45 Tactical, to name a few).
And I've tried a ton of belts, rigs, and holsters.
I've worn baggy clothes, untucked shirts, vests and cover garments that practically yelled "guy with a gun here!".
But no matter what, it was never truly comfortable, and certainly far from convenient.
The best place I found to carry a full-sized handgun was in the small of the back, which has quite a few drawbacks for self defense carry.
After years of battling the situation, I threw in the towel.
Now I carry a pocket pistol.
Every now and then I will carry my GP100.