After developing my hand load for a hunt I would zero my scope for hunting purposes shooting from a bench with a sand bag but the fore end of the rifle rested in my hand and my hand was supported by with the bag. With my best loads in .223, .243, .270 and .300 Win Mag I was always able to get 1/2 to 1 MOA at 100 yards. By "always" I don't mean every group - I mean I could get such consistently enough that I was very confident in the load, the rifle, the scope AND my shooting. Before hunting I would practice the same positions as in the Army - standing, kneeling, sitting and prone. Shooting prone with my hand supported by a bag I couldn't match my accuracy from the bench with my and supported by the bag, but still shot MOA regularly. When hunting with a rifle (or shotgun with slugs) I have always sought some object to stabilize the firearm, e.g., a rock, a log, a tree branch, a fence post, or a back pack. This approach has allowed me to take whitetails at more than 100 yards several times with Remington 12 Ga. 2 3/4" Sabot solid copper slugs. I took best mule deer (5 x 5) at well over 400 yards with my .270 rested in my hand and body rested on a rock about the size of compact car. I took a very small black bear at well over 400 yards shooting prone with my .300 Win Mag in my hand resting on a rock.
A few years ago I was visiting the father-in-law of my younger daughter. He is a competitive bench rest shooter with a 300 yard range on his property, The range has steel back stops and a solid concrete bench in a building on a concrete slab. Having never before touched his new rifle, a custom 6mm PPC with NightForce scope, I shot a 3 shot 1/2" group and followed with two 3 shot groups between 1/4" and 3/8".
However, I am no better than average on waterfowl or upland birds with a shotgun, or paper targets with a handgun.
To summarize: I think it is best (for me) to maximize the accuracy of my rifle, scope and load before attempting to maximize my personal shooting accuracy with that rifle. I think it is best to maximize my hunting accuracy practicing from different positions and at different ranges, and, where possible, use some natural support, especially for the hand under the fore end. I think it is best to take advantage of natural support objects while hunting to achieve the best hunting accuracy.
Wow, my fingers are tired.
P.S. Qualified as second best in my basic training company in the Army in 1969 despite several days in the infirmary with a respiratory illness just before qualifying. Nevertheless, there are many (probably thousands of) marksmen around the world much better than me or any of my friends.