No kids or wife. Frequent girlfriend sleepovers. Alert dog sleeps between my bed and the bedroom door. I'm a light sleeper.
I keep a loaded .40 5" Glock, extra mags, flashlight and KBar in my nightstand. Accessible within seconds. Cell phone and light switches are also immediately accessible. Can give knife or phone to girlfriend.
I have a massive fire and burglary resistant floorsafe at the foot of my bed. At night I open it completely and have access to an modest arsenal of guns, ammo and a kevlar vest (I obviously lock it during the day; if there were an emergency like a fire it would take less than 2 seconds push it shut and turn the lever). If I had a few extra moments to arm myself, I could retrieve body armor for self, shotgun or AR15 for self and revolver for girlfriend. Shotgun has full tube, 5 shots in sidesaddle, safety off, and empty chamber. AR15 has full 30 rd magazine (with many others ready) empty chamber, fire selector in "fire" position.
If flight is necessary, I'm on the ground floor and bedroom window can be opened and egress in under 30 seconds.
Soon I will install further measures to secure my bedroom including a solid door, rebar reinforcements, etc. But that's a project for another day.
As it stands, I'm very comfortable that I'm prepared for nearly any burglary. If I'm not there all of my valuables are locked up. If I'm home they BG is in for one hell of a surprise.