Sirsloops said:
"For HD pistols, I tend to lean more towards revolvers. Nothin like a S&W 686 with .357 mag HP's in the night stand. No fussing with safeties, slides, magazines, etc. Its always ready to go, grab it, and pull the DA trigger. Bang. Heck, the wife hates guns and she can shoot the thing without using any brain power. Just pull the trigger. I think there is a very low percentage of cases where a 15+rd magazine would have been any benefit in a HD situation. I still like shotguns better for their penetration properties, fear factor, and firepower."
+1 Good response, as well as others who have mentioned revolver and/or shotgun. When the adrenaline is flowing is not when you need to think safety on or not?, is a round chambered (indicators being next to worthless in low light and high anxiety)...or am I going to jam? etc.
Among revolvers - Used? S&W K-frame -- M65/66 3"-4". The 3" especially can double as a carry piece fairly effectively. Naturally, oddly the fewest made and as such are hardest to come by and pricier as a result. New? S&W 686 3". A little less carryable than the K-frames, but can shoot the nasty 125 .357s all day long--if so inclined. The 3" will help pare the weight back a smidgeon, and to optimize (and feel better about the negative trade-offs) to get the most out of the extra weight and $ (over a used K), go for the "+" (7 rd) model. For HD I might stoke it with warm +P .38s anyway, so my nod goes to the slightly handier/lighter K-frame.
Among the autos--Used? Smiths of prior gen. New? +1 on the Ruger SR9C. With its ancillary 17 rd extendo-grip/mag can go from carry piece to hi cap HD or range gun in a jiffy. XDM9 does this magic change act too (and maybe a few others?), but is a little pricier--so whatever fits you best in budget and hand. Carry not so much a factor and can spend a few more dollars? Smith M&P 9.