Home Defense Handgun...

The primary advantage of a .22 auto is that even a new shooter can fire it rapidly, on target. A .38 revolver, even if the DA trigger doesn't cause the first shot to go wide, can fall prey to recoil compensation where the novice puts the next five shots in the floor.

For home use by novices a condition 3 target .22 solves a few problems.
 
The Israelis use .22lr to dispatch bad guys because they can put the bullets right where they need to.
They are also trained to do so.

As I said earlier, I dont doubt their being lethal, its just that you need skill (or a lot of luck) to hit those small targets that will bring about a quick solution.
 
For a revolver I would recommend any model S&W .38 or .357 revolver you could find in good condition in that price range. Not going to be a lot for sale at $300.00. For a S/A a third generation S&W 9MM would be a good choice. I have found them to be very reliable guns.
 
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