1) Multiple sources have convinced me that the only HP slug that has the potential to function as designed out of a .380 is the 95 grain XTP.
2) Hornady advises that, for the XTP to function as designed, it needs a terminal velocity of 900 fps or greater.
3) Earlier this year, I worked up a load that clocked at about 940 fps @ 15 feet from my P238. (Sorry, I'm not where I can look up my notes. Fairly certain the powder was Unique, but I won't cite a charge from memory.). These slugs were also impressively accurate.
4) As a result, on those occasions when I carry a .380 (which is rare), the first magazine is charged with my XTP handloads, while the others have Win FP-FMJs.
5) It shouldn't need to be said, but no round should be carried that hasn't been tested for and demonstrated functional reliability from the pistol you carry.
6) If you ever have to shoot someone, the issue will be whether the circumstances warranted the use of potentially deadly force against an assailant, not the type of bullet employed.