Unlike .45LC with blow back, there is very little clean up in the breach and action needed when shooting bottle necked black powder .44-40 cartridges, mainly just the barrel.
Loooooooooove my Uberti 1866 yellowboy!! 45 Colt, solid brass frame with deep blued barrels and buttplate and gorgeous wood. Handles any and all 45 Colt loads...
Henry makes the Big Boy in 357/38 they can be had for under $750 and they are Made in the USA. If I wanted a 357/38 lever action it would be either a Henry or Marlin. I have a older 1894 in 44 mag I bought when they first came out 20+ years ago shoots flawlessly.
Uberti Win 73 Musket holds 17 .45 Colt cartridges.
As a 3 ring musket the accuracy potential can be limited compared to the 73 rifle variant.
Bootsie aka Long Johns Wolf