Oh, sure. You're going to resist a government armed with nukes and MRAPs.
The Vietnamese did.....and they won. (No offense to those who actually fought in that war - I recognize that they won after our politicians decided not to support the troops)
The Afghans did.....and they won - against Russia; and now against the US
The Islamic Extremists in Iraq are now winning with nothing more than small arms.
How exactly is a tyrant who takes over the US going to fight 400,000,000 with nuclear weapons? Nuclear weapons are a non-issue in wars between countries today, and even more of a non-issue in civil wars. There is no evidence of any country using nuclear weapons to suppress a revolution - not even in Syria.