If I am cocked and locked and I am identifying a threat, is my safety still engaged while IDing? Do I disengage the safety immediately prior to engaging a target? If so, that could be a minor tactical disadvantage.
Is a striker fired gun such as the P320 any safer than a CZ-75 in SA with the safety off?
In a struggle for the gun, would you like your adversary to be holding your point-and-squirt DA/SA or striker-fired gun with the safety off or no safety, or would you prefer to have a moment or moments while they try to figure out the safety and how it works?
I'd go cocked 'n' locked SA, but if you are even thinking "I might forget to disengage the safety", or, "I don't know when to engage or disengage the safety", definitely do something else.