Well, I'm very glad I have a .40 in these times, it's considerably easier to find than .38 and .357 although given a choice I have more fun with the .357. I really feel sorry for the 9mm and .22 people. Who ever thought that there'd be a shortage on those calibers?
I'm of the opinion that unless you're on the trail often and need to stay light, having guns in different calibers is a good idea.
Over the long term, I think the best plan would be to have guns in a couple popular calibers, like 9mm, .40, .45 etc., and when times are good, lay aside a stock for times like this.
All the smart people I know (this does not include myself btw) have plenty of ammo or reloading supplies stashed and are not concerned about this current frenzy, they have enough to weather it out. Grasshoppers like myself, on the other hand, are simply cutting back on their shooting or hounding sporting goods stores for new stock.
Ivan