Yes.
I built a lightweight pseudo Commander in the late 1970s. The frame was an alloy A&R Sales frame, the rest was scrounged Colt (slide) and G.I. parts.
After several years of shooting - no idea of how many rounds - the frame rails starting cracking away from the rear. However, I found out one afternoon when cleaning the poor darling AFTER shooting a combat match. It worked fine for the match.
I carried a Smith & Wesson Model 13 revolver as a Border Patrol Agent. I shot that gun a bunch with all sorts of loads. When the "L" frame revolvers came out, I bought a Model 581 and put the 13 into off-duty carry mode. At some point around that time, I noted the 13 was 'spitting' lead from the cylinder barrel gap. Then I noted a couple other things, like fore and aft play in the cylinder. The top strap seems to have stretched over time.
I still have both revolvers, they went too far with me to get rid of them. I might be able to have the M13 rebuilt, but I haven't done anything about it yet. At the moment, I consider it 'worn out'.