I have a "collection" of toys, but the bedside table gun for me is a 66-1, 4" or a 627PC. I have some others around the house in case they are needed.
I highly recommend revolvers for "middle of the night" scenarios. If there is any question as to whether it's loaded, and it should be loaded, its very easy to swing out the cylinder and check by feel in the dark. No fiddling with a mag and wondering if there is one in the chamber.
They are as easy to use as a spoon, and the remedy to an incredibly rare malfunction is to pull the trigger again. This is especially important for those who won't be practicing regularly.
Another consideration is the double action revolver trigger is it's own safety. A single action semi-auto might be fired without meaning to in a high stress situation without proper training and practice, or even with them. Though the DA revolver has no mechanical safety to fiddle with, the heavier trigger is a safety in and of itself. You have to mean it to fire it. Again goes to ease of use.
If you think 6 rounds aren't enough, well then the S&W 627 is an 8 rounder, as much as my 1911 mags.
My neighbor, and shooting buddy, is a smaller woman. She didn't like the recoil of my 442, but liked the way it fit her hand. She tried my Model 60 3" and again liked the fit, but thought the recoil was still a little stout for her taste. She also has tried the 627 5", the model 19 and the model 14. She didn't like any of the semi-autos due to difficulty racking.
She settled on a 686 with a 2.5" barrel. The L frame was better on recoil, but the shorter barrel kept the weight down a bit. It was the perfect compromise for her, and she shoots it VERY well. Her ammo of choice is 38 rather than 357, but that just makes the recoil in that L frame even more manageable.