Due to the fact that I live in a rental my go to is my carry which is a S&W M&P 45. Once I move it will be the 45 and an SKS 7.62x39 mm. Previous go to for home security was a 45 bersa thunder uc, before that a custom 1911 Colt 45. Always near was my 870 express remington loaded with the first shot of #6 copper plated, with the rest 000 buck shot.
I have owned and carried handguns for almost 35 years, so "then" covers a lot of territory, most of which I can no longer remember.... Today, though, my go-to/carry guns are a 9mm CZ75 on the hip and a Ruger +p .38 LCR in the pocket.
I have them stashed all over the house so it depends on what room I'm in. (No kids at home anymore). My nightstand gun for the past couple of years has been a S&W 686+ 3 inch, 7 shot loaded with .38 +P. There always a 1911 floating around as well...
Mossberg 590, 6 shots of 00 Buck and then 3 Slugs following them. Colt Night Defender on my hip and a S&W Airweight 38 bobbed hammer. Then the ever ready S&W Model 66 loaded with double tap hotload .357. I have a .380 Beretta Cheetah that the little woman could grab, but most likely she'd have the baby in the closet.
I promise I didn't try to make it look like a mall ninja weapon! - All Ive ever done to it was put a side saddle on it and pull a shell holder over the stock. The light on the end was a hand held I already had. I don't want to run out of ammo, and I don't want to be in the dark and not be able to see, or identify what I might have to shoot.
I live where fire arms have to be under lock and key, and running is required by law.
Back when I had need of a carry pistol it was a Star BM. Not that I had any say about it. At least until I could pick up a 1911 locally. And as soon as I could get my hands on a Vig, I'd loose the FAL. Third time out I was issued a Israeli 1911 and a Israeli issued Mosin Nagant. Still have a couple of them. Always carried a 1903 colt 32 as a backup.
Beretta M9, 18 round MDS mag, 147gr talon. Backed up by a 870 in the corner on my side with an MP15 under the bed. Wifes side is am M&P 9mm, that may change to another M9.