If we are going to go into interesting concepts that are far away from the OP question [and they ARE fun to pursue!
Yes they are fun, and if only the muckety-mucks at Glock would listen! The time has come for them to produce the G26 frame & barrel with the G19 grip, with a Gen2 frontstrap and the Gen4 backstrap!
I'd vote for the G21 or G30, in an SF frame [or Gen 4]
I voted for my Gen4 G-21, IMHO the G-21 renders a G-22 to the LGS consignment case; at least that's what happened with my G-22.
I'd go G21SF, with a .45acp to 10mm conversion barrel. I'd then look into other conversion barrels also, with a .22lr AA top end.
How about a G40 MOS 10mm with a Trijicon RMR optic, with a G41 .45acp conversion barrel, along with a .22 LR Advantage Arms conversion barrel?