um....when did a general purpose plinker/hunter/home defense rifle question turn into what can lay down enough suppression fire? last time I was in Virginia, the paper targets and feral pigs didn't have machine gun nests the the average punk breaking into your home doesn't pack an uzi and a AK47. you have to remember that a Nebraskan's definition of general purpose rifle is going to vary greatly from an Alaskan's definition. a 243, 257(roberts and weatherby), 6.5 grendel, 6.8 SPC, 7mm-08, 30-30, 308, 30-06, 7.62x54R, and 303(british and savage) are all going to fit the OP's definition of general purpose very well. he doesn't need a night vision holographic scope on his phased plasma rifle with 40 watt range. he needs a gun that can put a hole in paper at 25 yards just as well as it can drop a coyote at 200 yards and if he absolutely has to drop an intruder from across his living room.
I might be completely wrong but that is is about as general purpose as it gets and an AK47, 10/22, 357 lever action, Barrett 50 cal, and 12 gauge pump gun do not fit those criteria at all, a medium to lightweight bolt action rifle in any of the aforementioned calibers fits the bill exceedingly well.