Yes, with the careful attention of an armorer most pistols can be modified, even including the use of a buffer insert, and still maintain their reliability ...
A properly sized ejection port, an extended ejector with the forward edges radiused, beveled & "tuned" as necessary to aid in controling the ejection (including modifying the "timing" of the ejection), as well as the extractor being properly adjusted for tension & the hook beveled, polished and "tuned" ...
And then, if the maintenance of the pistols includes a careful inspection of the condition of the synthetic buffer material ... especially after each and every shooting exercise ...replacing them when they start to show wear, like cracks, deepening indentations, chips missing, etc..
These steps can enhance the basic reliability of the pistol, while still allowing the shooter the advantages to be gained from buffer use.
I considered my Combat Commander to be well broken in once it had reached 20,000 rounds of service life. Hammer & sear were replaced once, and springs as required by wear. I started to pay more attention to the ejection/extraction pattern of the pistol, and changed the recoil springs whenever the pattern changed more than a little.