I would not recommend the use of FMJ in the larger calibers. Why? Overpenetration.
.45 Ball WILL create a through and through wound of the human body. Most of the time it will do so, even if it hits bone.
Remember that the bullet itself does NOT cause incapacitation--it is the destruction of the internal structure, caused by a violent hydraulic displacement, that will induce shock and cause the attacker to cease functioning.
Now, it is common knowledge that a person who is pumped on pure adrenaline WILL fight on, or will/can travel amazing distances, even with lethal, fatal wounds inflicted. The phrase, "He was dead-he just didn't realize it yet" is all too true.
Thus, we always train--and have been told, numerous times through the experiences of those who have been there--that you aim center of mass of the body. This aiming area contains the "boiler works"--major arteries, the heart, lungs, etc. If, Heaven forbid, you HAVE to shoot, you want to hit the assailant with something that will create a massive, violent hydraulic displacement. When an object hits a fluid medium, the fluid displaced will be traveling for a short distance at the same speed as the projectile. Next, remember that the larger the impact cross-section, the larger the amount of fluid medium that is displaced by the impact.
A hollow point projectile is desireable because it expands (under most circumstances) and presents a wider cross section, thus causing more violent displacement of the fluid medium.