If you have a load that you are trying to tune up/improve, the easiest thing can sometimes be changing primer brands and working up again.
If you are tuning a load you will notice a range where the case fill ratio is the happiest.This will net you the lowest ES's with that primer/powder combo (sometimes this correlates with your accuracy node)
It is thought that it is a powder type, primer type & bullet weight vs. case fill ratio that makes up the majority of extreme spread.
Your developed load should be in the middle of a accuracy range of at least .3 tenths. Fretting over 1 tenth variations in powder to get your load shooting is not the best load choice. Choose a different range or a different primer/powder combo.
Getting below 25 fps goes into cartridge type X vs X type case design, as well as perfect bullet release. Perfect bullet release has much to do with bench rest style case prep and chamber dimensions etc.