tpc, lots of good info here, from a lot of experienced shooters sharing their methods of hitting the mark. Whatever prompted all these good posts, was certainly a good question! Whether you know it or not!
I'll just add that it's an important thing to know the point-blank range on whatever rifle you're using, for whatever purpose. My elk rifle, an '06, has a PBR, FOR ME, from 0 yards to a bit over 150. I've shot/hunted enough through the years to have a built-in confident mental knowledge of distance within that yardage. After that, when in doubt, I use my range finder if I have the opportunity and the time to use it. I use a fixed powered, duplexed haired 6X scope and leave the settings where they always stay, once I know I'm zeroed to where I want to be. This remains the same, year after year; I've got a zero that serves me best, and I leave it there.
On a shot while hunting, I use any rest I can use to steady myself. Sitting, kneeling and prone when using my daypack come into play when I've seen the game first and can use any of these methods to make a good, clean killing shot. I'm also a confident user of "Kentucky windage," too.
I'm very fortunate where I live to be able to shoot at any range I wish to practice at, and I've limited my shots to just a bit beyond 325 yds. I practice shooting over my daypack at this range every year prior to the hunting season to make sure everything in the scope setting and handload has remained the same as I like it. At this range, 325 yds., my '06 will print the shots of my reloads at right at 17" low (+- a bit depending on me and the weather on the day). That means to me I can still take some hair on the backline of a mature sized elk and still be in the kill zone. To this day, the farthest shot I've ever taken to kill an elk was ranged at 262 yds. I easily took "hair" a bit below the backline, and that's what practiced "Kentucky" does for you at the moment of the shot. You mentally know when to squeeze when the horizontal sets right. On a windless day, the vertical runs up along the backline of the front leg. If you can practice at your own range distance limit, you're so much more ahead of the game, and many questions are answered for you (IMO).
When I first started my resident hunting experiences in Wyoming, over 40 years ago, I met a shooter/hunter friend who said something I never forgot. This was back in the days before anyone had, or had ever really even heard of, a range finder. He said when in doubt of the range, always take a bit of hair on the backline (no daylight, ever). That's still good advice, and that's knowing what you and your rifle's limitations are, and that comes with practice.
And now, these days, I've always got my range finder with me on a hunt. What a great thing for a hunter, along with some practiced "Kentucky Windage" knowledge when needed to be put into play.
Just ramblings here from an old guy, and hope some of this helps. Good thought-provoking post, tpcollins, whether I knew what the question was or not!