I originally started carrying with a cross draw, but moved to strong-side carry before long. I very much liked the idea of being able to access my gun with either hand, and I already carried a knife on my belt on my right (strong) side.
I found I could not as easily conceal when carrying cross-draw style, as the gun as was infront of my hip. When carried on the side, it was more difficult for my right (strong) hand to grab and draw. Being carried slightly infront, it was more prone to showing when my jacket/shirt moved and seemed more recognizable as a whole. It could have been only recognizable to myself, and it might not be as big of a problem now that I am more comfortable carrying.
I carry on my strong side now, slightly behind the hip at about 4 o'clock position. This makes it very easy to conceal, as my cover garments never get pulled back far enough to expose it to my front (as hte gun is slightly behind me) and is generally blocked by my arm from the size, espcially if I have my hand in my pocket.
In terms of retension, I was never concerned with cross-draw in this respect. If someone was close enough to grab the gun from me, I suspect it would be fairly obvoius of his intensions and there are plenty of countering moves available. While its been some years since I have actively trained, I did study martial arts when I was younger and believe I could rely on some of the basic training to deflect an agressor from my holster. I think its safe to say that I am very far out of practice to attempt the advanced moves, though.
I will have to consider trying out a cross-draw carry again now that I am more comfortable with carrying in general. My attitude towards concealment has lessened since I started, so perhaps the biggest deterent (lack of ease of concealment) would no longer be an issue for me. I recognize the benefits for CD carry, though concealment is still paramount while at work, when I sit/drive the most.