Pressure is everything. If even the slightest bit of pressure gets bled off, you will lose acceleration, and acceleration is what counts. You start at 0, and gain speed all the way down a barrel, as the gasses expand, powder keeps burning, and the bullet approaches maximum speed. Wherever the leak is, from tiny and insignificant to large, it will effect acceleration and eventual muzzle velocity. If you welded that gap shut, you would find that maybe you have at most a 1% or so boost in velocity. That figure is absolute guesswork
In a lot of cases, I really believe that this effect is going to be truly insignificant. At pistol velocities 30 -50 fps won't make a significant difference, and I doubt that the difference would even be that high.
As was said before, each firearm will be different, and two identical revolvers may have big differences between them with identical ammunition.
I understand wanting to know the answer, you're learning. My thoughts, though, are that this is a total non issue. Choose the handgun and round you want, and don't worry about abstract things like cylinder gap effects.