Never underestimate the .44 special "combat revolver"
BUSGUNNER, my answer to your question is this: I would advocate a stainless or hardchromed S&W M29 with a 4" barrel as the best solution to the defensive revolver question. Get a competent, professional gunsmith, not some kitchen table gunsmith wanabe, to round off the grip frame and give it an action job.
Feed it Corbon, Hydrashok or Glaser, Federal or Remington .44 special HPs for defense against 2 legged predators, .44 magnum loads for use in the outback against 2 and 4 legged predators. Carry 2-4 speedloaders stoked with ammo for whichever situation you are addressing.
The .44 special HPs will be on par with .45ACP HPs for defense use, from all I've ever read. If you can get your hands on an old S&W M24, .44 special N frame, it will do everything mentioned above except dispatch wild boar or bear; it will do the job on deer and other "food" critters; the .44 mag is the answer for dangerous game in the lower 48. The bears of Alaska are in a whole 'nuther world.
Make no mistake: A .44 caliber "combat revolver" - 4" barrel, 6 shot cylinder, high performance HP loads - operated by a man/woman who knows what they are doing is going to be extremely effective as a self defense weapon;
this setup will do anything a 1911 in .45ACP will do, it just does it a bit differently.
Another outstanding setup currently available is S&W's "mountain gun" in .45 Colt with a 4" barrel; I picked up one back n January for the wife to have as her "home alone" gun. I have heard S&W is going to resurrect the model 24, .44 special. This would be another great choice.
As regards the 5 shot, 2 1/2" to 3" barrel pocket .44 specials, I consider them more of a backup gun myself. For summer carry, they beat the bejesus out of a Walther PPK in .380 or any of the other "mouse guns."