Coyote Caliber

If you are just shooting coyotes, then the 223, 22-250, or 220 are great options, as is the 204. I've shot quite a few coyotes with my 223 and my 220, but when I started seeing a lot of pigs, those rifles weren't quite enough to really anchor them. If I had a 243, I'd have gone to that, since it's a nice tweener caliber and good for small varmints and for deer and pigs. I do have a 260, so I decided to start using it for coyotes and pigs (and deer) and it's great. I load the Nosler 100 gr Ballistic Tip and it does all I can ask of a bullet.

But...back to just coyotes...I've found that my 223 with the little Nosler 40 gr Ballistic Tip does a fine job on them. And the velocity isn't that far behind my 220 with the 55 gr bullet.
 
223 or a little more expensive is the 22-250. But any gun I have In hand when I see a coyote turns into a coyote gun.
 
If we're talking over 300 yards, my vote would be for the .25-06. It still has enough power for one shot drops way out there...

Bingo

I have a .25-06 that is my go to deer rifle for longer range, but I'd imagine the 100 gr ballistic tips I load for it would serve as a good long range coyote round as well.

My dedicated varmint/yote rifle is a 6mm rem shooting a 60 gr Sierra HP but I have never shot a yote at very long range...yet

Those are my "top two" ideal coyote cartridges I have on hand.

Another good one would be a .257 Weatherby Mag but the ammo/brass is expensive and they burn barrels quick. Its a hot-rod of a cartridge though :D
 
+1 to reynolds357

220 swift. Don't even need to hold over at 350yds. Just put the crosshairs on the 'yote and pull the trigger.
 
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