Have you seen websites such as Buffalo Bore where they sell "Ruger Only" loads? Yeah. Any more questions? (OK this mostly applies to .45 LC, but Ruger is known for making TANKS).
Yes, and it VERY IMPORTANT that you don't run the real hot 45 Colt loads in a "New Vaquero".
Buffalo Bore does mention this in there description, but just because it's a Ruger 45 Colt, doesn't mean it will digest the "Ruger Only" loads any more. That all changed when they introduced the Smaller mid frame 45 Colts like the "New Vaquero". This is NOT the same gun as the older Large Frame Pre-2005 Vaquero.
http://www.midwayusa.com/product/21...t-long-colt-p-260-grain-jacketed-hollow-point