It certainly can and has been done, but I'm not sure it would be worth the time, expense, and effort. A basic reloading setup would probably cost less than having and extra cylinder made and may very well give you better results and be more economical than buying factory .45 ACP ammo in the long run. Big bore, straight-walled revolver cartridges are quite easy to reload and, in a relatively low-pressure round like .45 LC, the brass will last a very long time. Other than the brass, components are pretty much interchangeable between the two and cost the same. Also, "convertibles" with cylinders for .45 ACP and .45 LC sometimes give less than stellar accuracy with .45 ACP for a couple of reasons. Standard bullet weight for .45 LC is 250-255 gr while .45 ACP is 230 gr so, if the gun has fixed sights, there's a distinct possibility that it won't shoot to POA with one or the other. Also, many older .45 LC guns had larger groove diameters than most .45 ACP guns and thus produce better accuracy with either hollow-base bullets or slightly larger .454-.455" bullets as opposed to the more common .451-.452" that the .45 ACP uses. Frankly, with the current prices of ammunition of all calibers, reloading will probably be the only way to shoot affordably if you plan on shooting very much.