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I work from home, if I am wearing jeans that day, I put a .45 in a owb holster - if I am wearing shorts or warm up pants, I grab one of the pocket pistolas.
That said, I also have wall mounted "safes" (those little black clamshells that open with keys) inside a closet in my office, the living room and the garage. Inside each of those closets, I take one of the keys and use a twist-tie and affix a key to the inside of a hanger in a shirt or jacket (that my wife knows about). What that allows us to do is get access to a pistol in an event and we are not armed.
As far as the rest, I mounted a "U" bolt kind of thing to the floor of my closet in my office, each of the "not in use" pistols that are long term storage are in the original case with a cable lock around the handle so they can't get opened and then I ran a cable lock down through the handles of the stack of pistol cases and locked it to the floor. This way if there is ever a break, they have to work to steal the stack of pistols.
As far as the kids, they know I have them (although I dont know about you guys, but it seems to be out of sight out of mind) - I always have a cover shirt on. There are times when I have one in any stage of assemble (or disassembly) on a drafting table in my office - but the ammunition is locked up in ammo boxes in the basement, so even if kids got their hands on them, there are no bullets.
T