I trim every loading. Everything the same length, everything consistant, everything same as last time I loaded. Get the same results each time to the range. anneal every 4th load. You want to be consistant every load. Same shoulder bump,same neck tension, same seating depth.You find a load that shoots great in your rifle-Keep loading that load exact every time. Just makes sense.
Now if Bart chimes in ( smart guy). he will talk about throat erosion, which I have no doubt is real. I have well over 3000 rounds down my match 308 rifle and to this day, still seat every load the same as I did 2 years ago and still get same results on target. If the day comes that my groups start to get out of control , a new barrel will be ordered. And then the game starts all over to find the perfect load.
I have 9 rifles now and I have one load for each of them. I do not mess with 2 or 3 different loads for each rifle. One load per rifle. Same bullet, trim length,primer,powder and seating depth.