I don't see where grip angle or the size of our fat or thin hands matter, directly.
If the gun bites you, the gun is telling you that your hand is in the wrong place. You might not think so, but the gun doesn't care what you think.
If the relationship of where and how you holds the gun results in you getting bitten, you need to adjust that. Most people seem to have trouble figuring out how to adjust their grip, so they adjust the pistol instead.
It is easier in many cases to just modify the gun with a different hammer or beavertail or something than it is to learn how to hold the gun differently, particularly if the hold you need to keep from getting bitten is different than the hold you use on other guns.
Its not a matter of the gun, or your hand, its the way you fit the two of them together. Some guns, with some hands, just need to be a little differently put together than others in order to avoid being bitten.
Sometimes (though seldom with semi autos) its the load level that changes things. I've had it happen with revolvers, particularly in magnums. 900fps, all good, same bullet at 1200fps, get bit by triggerguard. Solution, change grips to a different style.
Simply going to a Pachmayr grip can make a world of difference. Lots of things are in play and there's about as many different ways to hold the gun as there are people. If the gun bites, something is wrong, somewhere. Figure out the fix and its all good again.