I'm sure I'm in the minority here, but being as the .243 will be traveling at almost 3k or more, will have a solid lead core, and will have the momentum of an itty bitty freight train trapped on turbo speed, i don't think that ANY bovine, when hit on bone that has brain behind it, is going to survive a hit from any size bullet. The impact is going to drive splinters into the tissue and the shock from that impact would be enough to induce a brain bleed, even if there was no penetration of lead into the actual cavity. Any cow type animal, when hit in the brain pan, should go down just as if it was hit with an 8 pound hammer swung by a burly rancher. If you don't see spray, by all means, follow the shot up.