A blow back gun has no locking system. The only thing keeping the slide shut is the weight of the slide and the recoil spring.
It's usually limited to low power rounds, like the .22LR, .380, .25 etc. When firing, the weight of slide and recoil spring prevent the gun from opening until the pressure inside has dropped to safe levels.
Locked breech guns have some method of locking the slide and barrel together briefly. The usual methods are the Browning tilting barrel, rotating barrels, and gas locking. When firing, the slide and barel are held together for the amount of time it takes for the pressure to drop. Blow back can work for larger calibers, (most submachine guns are blowback) but the operating parts are too heavy to be practical in a handgun.