I've learned a lot from this post. There are all sorts of techniques and products I plan on trying out.
Here's a few more of my own.
After shooting, I let the whole cylinder soak in a solution of Hoppes #9 over night. The next day I clean as usual, and to get the lead rings off the front of the cylinder, I scrub it with an old bronze .45 brush. Usually this removes the buildup in a matter of seconds with no special products.
Tired of the metal tip of your brush making contact with the frame when cleaning the barrel ? Wedge the cap from a wide mouth Hoppes bottle in there. It fits perfectly in my 686 and I can brush as briskly as I like !
After I'm done cleaning, I wipe the entire piece down with breakfree so that its soaked. Then I wrap it up in a plastic bag and store it for about a week (I rotate my guns for home protection). After that time period, I wipe the gun down with some clean patches, voila ! Brand spankin' new ! You would be surprised at the crud you can pull of when you let that puppy soak for a week, and the great thing about breakfree, is you don't have to lube or oil it afterwards. This process makes clean up MUCH easier as you progressively shoot.
Use that same old .45 bronze brush in the cylinders, that also works well for me.