Don't you have to buy the Weatherby MkV to get 7mm Weatherby Mag? I have long lusted after the idea, but the expensive rifle + super expensive ammo + total overkill of it all keeps me away. To make things even LESS practical, the one I want most is the EuroMark, with the beautiful hand-rubbed stock. Too beautiful to be damaged honestly.
If you are looking for a utterly practical WORKHORSE, you can't beat a mildly used Weatherby Vanguard S2 in either .308 or .270 and go to the range to figure out which are your favorite loads in the 150 - 165 gr and 130 gr ranges, respectively.
However, if you are like me and like something different, 6.5 is part of a newer generations of flat-shooting calibers, and there is no Vanguard in that caliber yet, so Ruger or Winchester are virtual tossups. There are some very nice deals on gunbroker for either of these right now with Vortex scope included! This is what I would do if in the market for a new whitetail harvester.