There are many nice .45ACP pistols in the price range you mention. For $750, you could get two brand-new Rugers...a P-97 semi-auto in .45ACP for carrying and home defense, and a Vaquero in .45LC for cowboy shooting.
If you just want to go with one, there are others that fit the bill as well. A good 1911 is well within your budget...there's the Springfield Loaded, which will set you back around $600, and which comes with many desirable upgrades included, such as Novak sights and an extended safety lever.
Then there's the Glock 21 (13+1 shots with pre-ban magazines)or its compact brother, the Glock 30 (10+1 shots)...they're both .45ACP, sturdy and reliable, and around $550 each brand new. Glock also makes a slimline .45, the Glock 36 which holds 6+1 rounds.
CZ makes a very accurate and solid pistol in .45ACP, the CZ-97, which can be had for under $500 in most places.
With a budget like yours, there's really very little you can't afford in the way of quality .45ACP pistols. Do yourself a favor and go to a good gunshop and see which one fits your hand the best and works for you...all the choices mentioned above are good for home defense, CCW and target shooting, and there are plenty of other pistols out there that fit your requirements both in caliber and price range.