Any factory round in a 243, excepting varmint ammunition, will kill deer. Deer are not hard to kill. Just good shot placement is needed. My son hunts with a 243 and every deer he's shot has gone down with one shot. I do know that the deer in Indiana are larger than they are in Texas IMO. I used to live in Indiana. But any 95 to 100 grain factory bullet will bring them down. Good luck and good hunting.