The real difference between Gen 1's and Gen 2's and later series Glocks is that the first two generations were "2-pin" Glocks. Sometime during the 2nd Gen or at least 3rd gen on, all Glocks are 3-pin. On 2-pin Glocks, the Locking Block is not pinned in place. The third pin pins the locking block in place.
When all Glocks were 9mm's there was no need to pin the locking block in place. Glock later discovered that with higher pressure rounds, like the .40, the locking blocks would come loose. So, they started pinning them.
The bottom line is that I would steer clear of a 2-pin Glock in the higher pressure calibers like.40S&W.